Spectral Analysis of Effect of Risperidone on the Inhibition of Polyinosinic-polycytidylic Acid to Protein

Abstract

Abstract: In this paper, the effects of risperidone on the inhibition of serum albumin by polyinosinic-polycytidylic acid in the presence of five common metal elements in plasma were investigated by spectrometric method. The results showed that under the influence of risperidone, polyinosinic-polycytidylic acid inhibited the fluorescence of proteins in a dynamic quenching mode. Various constants, inhibition sites, interaction forces, binding sites and synergies were determined. The addition of copper and nickel only slightly increased the inhibition, but also weakened by chromium, manganese and magnesium.

Key words: Inhibition mode, serum albumin, metallic element, polyinosinic-polycytidylic acid

CLC Number:

O657.3

LIU Li, ZHANG Lijun. Spectral Analysis of Effect of Risperidone on the Inhibition of Polyinosinic-polycytidylic Acid to Protein[J]. Journal of Qujing Normal University, 2023, 42(3): 15-21.

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