Abstract: Co(II) meso-4 (4-carboxyl phenyl) porphyrin (CoTCPP) was synthesized by TCPP and Co(OAc)2.. Then the interaction between CoTCPP and bovine serum albumin (BSA) under the physiological condition was studied using the fluorescence quenching method. The results indicated that the fluorescence intensity of BSA has decreased with the concentration increase of CoTCPP. It also showed that the quenching mechanism of the combination of BSA with CoTCPP is a static quenching procedure. All of these provided some important information for further study of CoTCPP and its organism.

Key words: porphyrin, metal porphyrin, bovine serum albumin, fluorescence spectrum