Abstract: Ancient humans were often helpless in the face of disease, resulting in many associated totems, rituals, and myths.Plague writing has always been the topic of Chinese and foreign literature creation, which has gone through the process from statement to Metaphor, from non-fiction to fiction. The writer becomes the time recorder, the literature becomes the epidemic witness. In the face of such a world-wide epidemic disease, Chinese writers should assume what responsibilities, "assume" and "intervene" is a writer's conscience, not in front of the facts to remain silent, when a witness to the epidemic.It's human nature for writers to write about epidemics with their individual voices. The writer's creation should have a kind of world vision, inherit the creation method of the World Classic Literature, create the new classic which belongs to our time.

Key words: Epidemic disease, Literature, Statement, Metaphor, Classic