光谱分析利培酮影响聚肌胞对蛋白的抑制

曲靖师范学院学报 ›› 2023, Vol. 42 ›› Issue (3): 15-21.

光谱分析利培酮影响聚肌胞对蛋白的抑制

刘里, 张丽君

曲靖师范学院化学与环境科学学院,云南曲靖 655011

收稿日期:2022-03-21 出版日期:2023-05-26 发布日期:2023-06-30
作者简介:刘里,曲靖师范学院化学与环境科学学院副教授,主要从事药物化学和分子发光学理论与应用研究.
基金资助:
国家自然科学基金项目“模拟酶荧光素抑制剂的筛选及分析应用研究”(21804079);云南省地方本科高校(部分)基础研究联合专项重点项目“氧杂蒽类过氧化物模拟酶活性的研究及其分析应用”(202001BA070001-127);上海师范大学资源化学教育部重点实验室开放课题“荧光素基纳米材料的模拟酶活性及分析应用研究”.

Spectral Analysis of Effect of Risperidone on the Inhibition of Polyinosinic-polycytidylic Acid to Protein

LIU Li, ZHANG Lijun

School of Chemistry and Chemical Engineering,Qujing Normal University, Qujing Yunnan 655011,China

Received:2022-03-21 Published:2023-05-26 Online:2023-06-30

摘要/Abstract

摘要： 利用光谱法探究在血浆中常见的5种金属元素存在下,利培酮对聚肌胞抑制血清白蛋白的影响. 研究表明:在利培酮的影响下,聚肌胞以动态猝灭的模式对蛋白的荧光进行抑制. 确定了各种常数、抑制位点、相互作用力、结合部位和协同作用等. 添加的铜和镍只能略微增加抑制作用,铬、锰和镁反而削弱了抑制作用.

关键词: 抑制模式, 血清白蛋白, 金属元素, 聚肌胞

Abstract: In this paper, the effects of risperidone on the inhibition of serum albumin by polyinosinic-polycytidylic acid in the presence of five common metal elements in plasma were investigated by spectrometric method. The results showed that under the influence of risperidone, polyinosinic-polycytidylic acid inhibited the fluorescence of proteins in a dynamic quenching mode. Various constants, inhibition sites, interaction forces, binding sites and synergies were determined. The addition of copper and nickel only slightly increased the inhibition, but also weakened by chromium, manganese and magnesium.

Key words: Inhibition mode, serum albumin, metallic element, polyinosinic-polycytidylic acid

中图分类号:

O657.3

刘里, 张丽君. 光谱分析利培酮影响聚肌胞对蛋白的抑制[J]. 曲靖师范学院学报, 2023, 42(3): 15-21.

LIU Li, ZHANG Lijun. Spectral Analysis of Effect of Risperidone on the Inhibition of Polyinosinic-polycytidylic Acid to Protein[J]. Journal of Qujing Normal University, 2023, 42(3): 15-21.

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