金属催化下构建五元、六元并吡咯骨架的双环化反应研究

曲靖师范学院学报 ›› 2020, Vol. 39 ›› Issue (6): 40-44.

金属催化下构建五元、六元并吡咯骨架的双环化反应研究

范威

滁州城市职业学院科研处,安徽滁州 239000

收稿日期:2020-06-30 出版日期:2020-11-26 发布日期:2021-01-13
作者简介:范威,滁州城市职业学院科研处讲师,博士,主要从事有机化学研究.
基金资助:
滁州城市职业学院院级科研项目“酸控制下萘啶母核的选择性修饰”(2020zk04).

Study of Metal-catalyzed Bicyclization of Constructing Five/Six-membered Pyrrole Skeletons

FAN Wei

Department of Research and Developemnt, Chuzhou City Vocation College, Chuzhou Anhui 239000, P. R. China

Received:2020-06-30 Published:2020-11-26 Online:2021-01-13

摘要/Abstract

摘要： 吡咯衍生物可用作止痛药、消炎药、EP₁受体拮抗剂等.同时,该骨架还广泛存在于Isamoltane、Obatoclax、Tolmetin等天然产物中,是最有价值的杂环之一. 金属催化下的双环化反应在构建五元并吡咯和六元并吡咯中得到了广泛报道,如何充分发挥已有文献的优点,避免缺点的重复,将为吡咯合成新法的研究提供借鉴.

关键词: 金属催化, 五元并吡咯, 六元并吡咯

Abstract: Pyrroles can be used as analgesics, anti-inflammatory drugs, EP1 receptor antagonists, etc. At the same time, the skeleton is also widely present in natural products such as Isamoltane, Obatoclax and Tolmetin, and it is one of the most valuable heterocycles. The metal-catalyzed bicyclization reaction has been widely reported in the construction of five-membered and six-membered pyrrole. How to make full use of the advantages of the existing literature and avoid the repetition of shortcomings will provide a reference for the research on the new method of pyrrole synthesis.

Key words: metal-catalyzed, five-membered pyrrole, six-membered pyrrole

中图分类号:

O626

范威. 金属催化下构建五元、六元并吡咯骨架的双环化反应研究[J]. 曲靖师范学院学报, 2020, 39(6): 40-44.

FAN Wei. Study of Metal-catalyzed Bicyclization of Constructing Five/Six-membered Pyrrole Skeletons[J]. Journal of Qujing Normal University, 2020, 39(6): 40-44.

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