4-羧基苯基金属钴卟啉配合物的合成及其性质研究

曲靖师范学院学报 ›› 2018, Vol. 37 ›› Issue (6): 34-37.

4-羧基苯基金属钴卟啉配合物的合成及其性质研究

卢新生,李娜,孙万军,李彪

甘肃民族师范学院化学与生命科学系,甘肃合作 747000

收稿日期:2018-07-14 出版日期:2018-11-26
作者简介:卢新生,甘肃民族师范学院化学与生命科学系副教授,主要从事物质成分分析研究.
基金资助:
甘肃教育科学“十二五”规划课题“民族高校化学专业分析化学实验课程内容的整合及模块化研究”(GS[2011]GHBG071).

Synthesis and Properties of 4-Carboxylic Phenyl Metallic Cobalt Porphyrin Complexe

Lu XinSheng, Li Na, Sun WanJun, Li Biao

Chemistry and Life Science Department, Gansu Normal University for Nationalities, Hezuo Gansu 747000, China

Received:2018-07-14 Published:2018-11-26

摘要/Abstract

摘要： 以meso-四(4-羧基苯基)自由卟啉与醋酸钴为原料制备了meso-四-(4-羧基苯基)金属钴卟啉配合物CoTCPP,在常温和生理pH下,运用了荧光光谱法探究了CoTCPP牛血清白蛋白(BSA)溶液的相互作用,实验表明:BSA分子具备比较强地内源荧光发射,该卟啉CoTCPP对其荧光有猝灭作用.另外,依据Stren-Volmer的方程确定了它们之间荧光猝灭机理为静态猝灭.这就对于进一步发现四(4-羧基苯基)金属钴卟啉配合物以及衍生物在生物体内的功用提供了一些重要信息.

关键词: 卟啉, 金属卟啉, 牛血清白蛋白, 荧光光谱

Abstract: Co(II) meso-4 (4-carboxyl phenyl) porphyrin (CoTCPP) was synthesized by TCPP and Co(OAc)2.. Then the interaction between CoTCPP and bovine serum albumin (BSA) under the physiological condition was studied using the fluorescence quenching method. The results indicated that the fluorescence intensity of BSA has decreased with the concentration increase of CoTCPP. It also showed that the quenching mechanism of the combination of BSA with CoTCPP is a static quenching procedure. All of these provided some important information for further study of CoTCPP and its organism.

Key words: porphyrin, metal porphyrin, bovine serum albumin, fluorescence spectrum

中图分类号:

O635.2

卢新生,李娜,孙万军,李彪. 4-羧基苯基金属钴卟啉配合物的合成及其性质研究[J]. 曲靖师范学院学报, 2018, 37(6): 34-37.

Lu XinSheng, Li Na, Sun WanJun, Li Biao. Synthesis and Properties of 4-Carboxylic Phenyl Metallic Cobalt Porphyrin Complexe[J]. JOURNAL OF QUJING NORMAL UNIVERSITY, 2018, 37(6): 34-37.